Mordaunt CE, Jianu JM, Laufer BI, Zhu Y ,Dunaway KW ,Bakulski KM ,Feinberg JI ,Volk HE, Lyall K, Croen LA, Newschaffer CJ, Ozonoff S, Hertz-Picciotto I, Fallin DM, Schmidt RJ, LaSalle JM. Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. bioRxiv.


Mordaunt CE, Park BY, Bakulski KM, Feinberg JI, Croen LA, Ladd-Acosta C, Newschaffer CJ, Volk HE, Ozonoff S, Hertz-Picciotto I, LaSalle JM, Schmidt RJ, Fallin MD. A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood. Molecular Autism. 

Lopez SJ, Laufer BI, Beitnere U, Berg E, Silverman JL, Segal DJ, LaSalle JM. Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Human Molecular Genetics.

Vogel Ciernia A*, Laufer BI*, Hwang H, Dunaway KW, Mordaunt CE, Coulson RL, Yasui DH, LaSalle JM. Epigenomic convergence of genetic and immune risk factors in autism brain. Cerebral Cortex.

Laufer BI, Hwang H, Vogel Ciernia A, Mordaunt CE, LaSalle JM. Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disease insights. Epigenetics.

Zhu Y, Mordaunt CE, Yasui DH, Marathe R, Coulson RL, Dunaway KW, Jianu JM, Walker CK, Ozonoff S, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Human Molecular Genetics.

Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. Epigenetics & Chromatin.

Lopez SJ, Segal DJ, LaSalle JM. UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease. Frontiers in Molecular Neuroscience


Ciernia AV, Yasui DH, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Knotts T, Rutkowsky J, Ramsey JJ, Crawley JN, LaSalle JM. August 2018. MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome. Human Molecular Genetics.

Coulson RL, Powell WT, Yasui DH, Dileep G, Resnick J, LaSalle JM. August 2018. Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN. Human Molecular Genetics.

Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali M, LaSalle JM, Medici V. July 2018. Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. Human Molecular Genetics.

Adhikari A, Copping NA, Onaga B, Pride MC, Coulson RL, Yang M, Yasui DH, LaSalle JM, Silverman JL. May 2018. Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome. Neurobiol Learn Mem.

Coulson R, Yasui D, Dunaway K, Laufer BI, Vogel Ciernia A, Mordaunt C, Totah T, LaSalle JM. May 2018. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications.

Vogel Ciernia A*, Laufer BI*, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH. April 2018. Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics.


Vogel Ciernia A, Careaga M, LaSalle JM, Ashwood P. November 2017. Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism. Glia.

Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike S, Segal DJ, LaSalle JM. September 2017. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics.

Vogel Ciernia A, Pride M, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM. March 2017. Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet.

Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. January 2017. A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies. Epigenetics.


Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. December 2016. Placental methylome analysis from a prospective autism study. Mol Autism.

Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. December 2016. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells.

Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Ciernia AV, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike S, Korf I, LaSalle JM. December 2016. Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes Epigenetics. Cell Rep.

Yasui DH, Peedicayil J, Grayson DR (Editors). November 2016. Neuropsychiatric Disorders and Epigenetics. Translational Epigenetics Series, Elsevier. 

Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. September 2016. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics.

Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. June 2016. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet.

Ciernia AV, LaSalle J. May 2016. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nat Rev Neurosci.

Rube HT, Lee W, Hejna M, Chen H, Yasui DH, Hess JF, LaSalle JM, Song JS, Gong Q. March 2016. Sequence features accurately predict genome-wide MeCP2 binding in vivo. Nat Commun.

Crawley JN, Heyer WD, LaSalle JM. March 2016. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet.


LaSalle JM, Reiter LT, Chamberlain SJ. October 2015. Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. Epigenomics.

Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. August 2015. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet.

Powell WT, LaSalle JM. June 2015. Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment. Hum Mol Genet.


Lee W, Yun JM, Woods R, Dunaway K, Yasui DH, Lasalle JM, Gong Q. July 2014. MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons. Hum Mol Genet.

Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. April 2014. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res.

Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME. March 2014. Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis. Front Immunol.


Schroeder DI, LaSalle JM. December 2013. How has the study of the human placenta aided our understanding of partially methylated genes?. Epigenomics.

Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, Lasalle JM. December 2013. Mice with an isoform-ablating Mecp2-exon 1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum Mol Genet. [Epub ahead of print]

Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM. November 2013. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics.

Powell WT, Coulson RL, Gonzales ML, Crary FK, Wong SS, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chédin F, LaSalle JM. August 2013. R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc Natl Acad Sci U S A. 110(34):13938-43.

Powell WT, Coulson RL, Crary FK, Wong SS, Ach RA, Tsang P, Yamada NA, Yasui DH, Lasalle JM. June 2013. A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet. [Epub ahead of print]

Lasalle JM, Powell WT, Yasui DH. May 2013. Epigenetic layers and players underlying neurodevelopment. Trends Neurosci. [Epub ahead of print]

Lasalle JM. May 2013. Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J Hum Genet. [Epub ahead of print]

Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JM. April 2013. The human placenta methylome. Proc Natl Acad Sci U S A. 110(15):6037-42.

Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. January 2013. MeCP2 modulates gene expression pathways in astrocytes. Mol Autism. 4(1):3


Medici V, Shibata NM, Kharbanda KK, Lasalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. September 2012. Wilson’s disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology.

Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM. October 2012. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen. 53(8):589-98.

Gonzales ML, Adams S, Dunaway KW, LaSalle JM. July 2012. Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. Mol Cell Biol. 32(14):2894-903.

Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM. June 2012. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet. 21(11):2399-411.

Martins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RH. January 2012. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics. 7(1):71-82.



Scoles HA, Urraca N, Chadwick SW, Reiter LT, Lasalle JM. December 2011. Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples. Mol Autism. 2(1):19.

Yasui DH, Scoles HA, Horike S, Meguro-Horike M, Dunaway KW, Schroeder DI, Lasalle JM. November 2011. 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet. 20(22):4311-23.

Schroeder DI, Lott P, Korf I, LaSalle JM. October 2011. Large-scale methylation domains mark a functional subset of neuronally expressed genes. Genome Res. 21(10):1583-91.

Meguro-Horike M, Yasui DH, Powell W, Schroeder DI, Oshimura M, Lasalle JM, Horike S. October 2011. Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet. 20(19):3798-810.

LaSalle JM. July 2011. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics. 6(7):862-9.

Artuso R, Papa FT, Grillo E, Mucciolo M, Yasui DH, Dunaway KW, Disciglio V, Mencarelli MA, Pollazzon M, Zappella M, Hayek G, Mari F, Renieri A, Lasalle JM, Ariani F. July 2011. Investigation of modifier genes within copy number variations in Rett syndrome. J Hum Genet. 56(7):508-15.

Singleton MK, Gonzales ML, Leung KN, Yasui DH, Schroeder DI, Dunaway K, LaSalle JM. March 2011. MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol Dis. 43(1):190-200.

Leung KN, Chamberlain SJ, Lalande M, LaSalle JM. February 2011. Neuronal chromatin dynamics of imprinting in development and disease. J Cell Biochem. 112(2):365-73

Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S, Gordon SC, Podda M, Gershwin ME, Selmi C, Lasalle JM. January 2011. Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics. 25;6(1).



Gonzales ML, LaSalle JM. April 2010. The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders. Curr Psychiatry Rep. 12(2): 127–134.


Adegbola AA, Gonzales ML, Chess A, LaSalle JM, Cox GF. January 2009. A novel hypomorphic MECP2 point mutation is associated with a neuropsychiatric phenotype. Hum Genet. 124(6):615-23.

Yasui DH, and LaSalle JM. 2009. Evolving role of MeCP2 in Rett syndrome and autism. Epigenomics. 1:119-130

Leung KN, Vallero RO, DuBose AJ, Resnick JL, LaSalle JM. 2009. Imprinting regulates mammalian snoRNAencoding chromatin decondensation and neuronal nucleolar size. Hum. Mol. Genet., 18:4227-4238. PMCID: 19656775

Swanberg SE, Nagarajan RP, Peddada S, Yasui DH, LaSalle JM. 2009. Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Hum. Mol Genet. 18:525-534. PMCID: 19000991


Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. 2008. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 1(3):169-78

Hogart A, Patzel KA, and LaSalle JM. 2008. Gender influences monoallelic expression of ATP10A in human brain. Hum Genet. 2008 October; 124(3): 235–242. PMID: 18726118, NIHMSID # 88432

Hogart A, Leung KN, Wang NJ, Wu DJ, Driscoll J, Vallero RO, Schanen NC, LaSalle JM. 2008. Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J. Med. Genet., 46:86-93. PMCID: 18835857

Wang NJ, Parokonny AS, Thatcher KN, Driscoll J, Malone BM, Sigman M, LaSalle JM, Schanen NC. 2008. Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15, BMC Genetics, 9:2. PMCID: 18177502


Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, LaSalle JM. 2007. Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc. Natl. Acad. Sci. 104:19416-19421. PMCID: 18042715

Hogart A, Nagarajan RP, Patzel KA, Yasui DH, LaSalle JM. 2007. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum. Mol. Genet. 16:691-703. PMCID: 17339270


Nagarajan RP, Hogart A, Gwye Y, Martin M, and LaSalle JM. 2006. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation Epigenetics, 4:172-182. PMCID: 17486179


Thatcher KN, Peddada S, Yasui DH, and LaSalle JM. 2005. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum. Mol. Genet. 14:785-797. PMCID: 15689352

Samaco RC, Hogart A, and LaSalle JM. 2005. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum. Mol. Genet. 14:483-492. PMCID: 15615769


Samaco RC, Nagarajan RP, Braunschweig D, and LaSalle JM. 2004. Multiple pathways regulate MeCP2 expression in normal human brain development and exhibit defects in autism-spectrum disorders. Hum. Mol. Genet. 13:629-639. PMCID: 14734626


Balmer D, Arredondo J, Samaco RC, and LaSalle JM. 2002. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth but do not affect imprinted gene expression in blood or brain. Hum. Genet., 110:545-552. PMCID: 12107440


Balmer D and LaSalle JM. 2001. Clonal maintenance of imprinted expression of SNRPN and IPW in normal lymphocytes: Correlation with allele-specific methylation of SNRPN intron 1 but not intron 7. Hum. Genet.;108:116-122. PMCID: 11281449


LaSalle JM., R. Ritchie, H. Glatt, and M. Lalande. 1998. Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes. Proc. Natl. Acad. Sci. 95:1675-1680. PMCID: 9465075


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LaSalle JM, Lalande M. 1995. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. Nat Genet.