2017

Vogel Ciernia A, Pride M, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM. March 2017. Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet.

Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. January 2017. A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies. Epigenetics.

2016


Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. December 2016. Placental methylome analysis from a prospective autism study. Mol Autism.

Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. December 2016. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells.

Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Ciernia AV, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike S, Korf I, LaSalle JM. December 2016. Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes Epigenetics. Cell Rep.

Yasui DH, Peedicayil J, Grayson DR (Editors). November 2016. Neuropsychiatric Disorders and Epigenetics. Translational Epigenetics Series, Elsevier. 

Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. September 2016. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics.

Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. June 2016. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet.

Ciernia AV, LaSalle J. May 2016. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nat Rev Neurosci.

Rube HT, Lee W, Hejna M, Chen H, Yasui DH, Hess JF, LaSalle JM, Song JS, Gong Q. March 2016. Sequence features accurately predict genome-wide MeCP2 binding in vivo. Nat Commun.

Crawley JN, Heyer WD, LaSalle JM. March 2016. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet.

2015


LaSalle JM, Reiter LT, Chamberlain SJ. October 2015. Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. Epigenomics.

Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. August 2015. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet.


Powell WT, LaSalle JM. June 2015. Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment. Hum Mol Genet.

2014


Lee W, Yun JM, Woods R, Dunaway K, Yasui DH, Lasalle JM, Gong Q. July 2014. MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons. Hum Mol Genet.


Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. April 2014. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res.


Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME. March 2014. Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis. Front Immunol.

2013


Schroeder DI, LaSalle JM. December 2013. How has the study of the human placenta aided our understanding of partially methylated genes?. Epigenomics.

Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, Lasalle JM. December 2013. Mice with an isoform-ablating Mecp2-exon 1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum Mol Genet. [Epub ahead of print]

Medici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JM. November 2013. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics.


Powell WT, Coulson RL, Gonzales ML, Crary FK, Wong SS, Adams S, Ach RA, Tsang P, Yamada NA, Yasui DH, Chédin F, LaSalle JM. August 2013. R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc Natl Acad Sci U S A. 110(34):13938-43.


Powell WT, Coulson RL, Crary FK, Wong SS, Ach RA, Tsang P, Yamada NA, Yasui DH, Lasalle JM. June 2013. A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet. [Epub ahead of print]


Lasalle JM, Powell WT, Yasui DH. May 2013. Epigenetic layers and players underlying neurodevelopment. Trends Neurosci. [Epub ahead of print]

Lasalle JM. May 2013. Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J Hum Genet. [Epub ahead of print]

Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JM. April 2013. The human placenta methylome. Proc Natl Acad Sci U S A. 110(15):6037-42.

Yasui DH, Xu H, Dunaway KW, Lasalle JM, Jin LW, Maezawa I. January 2013. MeCP2 modulates gene expression pathways in astrocytes. Mol Autism. 4(1):3

2012


Medici V, Shibata NM, Kharbanda KK, Lasalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. September 2012. Wilson’s disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology.

Mitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM. October 2012. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environ Mol Mutagen. 53(8):589-98.

Gonzales ML, Adams S, Dunaway KW, LaSalle JM. July 2012. Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation. Mol Cell Biol. 32(14):2894-903.

Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM. June 2012. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet. 21(11):2399-411.


Martins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RH. January 2012. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics. 7(1):71-82.

2011


Scoles HA, Urraca N, Chadwick SW, Reiter LT, Lasalle JM. December 2011. Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples. Mol Autism. 2(1):19.

Yasui DH, Scoles HA, Horike S, Meguro-Horike M, Dunaway KW, Schroeder DI, Lasalle JM. November 2011. 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet. 20(22):4311-23.

Schroeder DI, Lott P, Korf I, LaSalle JM. October 2011. Large-scale methylation domains mark a functional subset of neuronally expressed genes. Genome Res. 21(10):1583-91.


Meguro-Horike M, Yasui DH, Powell W, Schroeder DI, Oshimura M, Lasalle JM, Horike S. October 2011. Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet. 20(19):3798-810.

LaSalle JM. July 2011. A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics. 6(7):862-9.

Artuso R, Papa FT, Grillo E, Mucciolo M, Yasui DH, Dunaway KW, Disciglio V, Mencarelli MA, Pollazzon M, Zappella M, Hayek G, Mari F, Renieri A, Lasalle JM, Ariani F. July 2011. Investigation of modifier genes within copy number variations in Rett syndrome. J Hum Genet. 56(7):508-15.

Singleton MK, Gonzales ML, Leung KN, Yasui DH, Schroeder DI, Dunaway K, LaSalle JM. March 2011. MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol Dis. 43(1):190-200.

Leung KN, Chamberlain SJ, Lalande M, LaSalle JM. February 2011. Neuronal chromatin dynamics of imprinting in development and disease. J Cell Biochem. 112(2):365-73


Mitchell MM, Lleo A, Zammataro L, Mayo MJ, Invernizzi P, Bach N, Shimoda S, Gordon SC, Podda M, Gershwin ME, Selmi C, Lasalle JM. January 2011. Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis. Epigenetics. 25;6(1).

2010


Gonzales ML, LaSalle JM. April 2010. The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders. Curr Psychiatry Rep. 12(2): 127–134.

2009


Adegbola AA, Gonzales ML, Chess A, LaSalle JM, Cox GF. January 2009. A novel hypomorphic MECP2 point mutation is associated with a neuropsychiatric phenotype. Hum Genet. 124(6):615-23.

Yasui DH, and LaSalle JM. 2009. Evolving role of MeCP2 in Rett syndrome and autism. Epigenomics. 1:119-130

Leung KN, Vallero RO, DuBose AJ, Resnick JL, LaSalle JM. 2009. Imprinting regulates mammalian snoRNAencoding chromatin decondensation and neuronal nucleolar size. Hum. Mol. Genet., 18:4227-4238. PMCID: 19656775

Swanberg SE, Nagarajan RP, Peddada S, Yasui DH, LaSalle JM. 2009. Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Hum. Mol Genet. 18:525-534. PMCID: 19000991

2008


Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. 2008. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 1(3):169-78

Hogart A, Patzel KA, and LaSalle JM. 2008. Gender influences monoallelic expression of ATP10A in human brain. Hum Genet. 2008 October; 124(3): 235–242. PMID: 18726118, NIHMSID # 88432

Hogart A, Leung KN, Wang NJ, Wu DJ, Driscoll J, Vallero RO, Schanen NC, LaSalle JM. 2008. Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J. Med. Genet., 46:86-93. PMCID: 18835857

Wang NJ, Parokonny AS, Thatcher KN, Driscoll J, Malone BM, Sigman M, LaSalle JM, Schanen NC. 2008. Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15, BMC Genetics, 9:2. PMCID: 18177502

2007


Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, LaSalle JM. 2007. Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc. Natl. Acad. Sci. 104:19416-19421. PMCID: 18042715

Hogart A, Nagarajan RP, Patzel KA, Yasui DH, LaSalle JM. 2007. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum. Mol. Genet. 16:691-703. PMCID: 17339270

2006


Nagarajan RP, Hogart A, Gwye Y, Martin M, and LaSalle JM. 2006. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation Epigenetics, 4:172-182. PMCID: 17486179

2005


Thatcher KN, Peddada S, Yasui DH, and LaSalle JM. 2005. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum. Mol. Genet. 14:785-797. PMCID: 15689352

Samaco RC, Hogart A, and LaSalle JM. 2005. Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum. Mol. Genet. 14:483-492. PMCID: 15615769

2004


Samaco RC, Nagarajan RP, Braunschweig D, and LaSalle JM. 2004. Multiple pathways regulate MeCP2 expression in normal human brain development and exhibit defects in autism-spectrum disorders. Hum. Mol. Genet. 13:629-639. PMCID: 14734626

2002


Balmer D, Arredondo J, Samaco RC, and LaSalle JM. 2002. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth but do not affect imprinted gene expression in blood or brain. Hum. Genet., 110:545-552. PMCID: 12107440

2001


Balmer D and LaSalle JM. 2001. Clonal maintenance of imprinted expression of SNRPN and IPW in normal lymphocytes: Correlation with allele-specific methylation of SNRPN intron 1 but not intron 7. Hum. Genet.;108:116-122. PMCID: 11281449

1998


LaSalle JM., R. Ritchie, H. Glatt, and M. Lalande. 1998. Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes. Proc. Natl. Acad. Sci. 95:1675-1680. PMCID: 9465075

1996


LaSalle JM, Lalande M. 1996. Homologous association of oppositely imprinted chromosomal domains. Science. 272:725-728. PMCID: 8614834

1995


LaSalle JM, Lalande M. 1995. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. Nat Genet.